Endocrine Abstracts

Background: Distal symmetric polyneuropathy (DSPN) is one of the most prevalent chronic complications of diabetes and the most common cause in the pathway to diabetic foot ulceration. Screening for DSPN enables early intervention and prevention of complications. The Semmes-Weinstein Monofilament Examination (SWME) is currently the method of choice to screen DSPN, but ideally two neurologic tests should be used. The Michigan Neuropathy Screening Instrument (MNSI), which evaluat...

Therapeutic options for patients with severe obesity are limited. Low energy meal replacement regimes can induce significant short-term weight loss and improvements in metabolic variables. We sought to estimate the effect size on adiposity and cardiovascular risk factors of a relatively inexpensive 24-week regime based on meal replacement with semi-skimmed milk in severely obese adults. A retrospective cohort analysis showed that of 206 patients in our hospital-based bariatric...

Combination of Turner syndrome (TS) and classical congenital adrenal hyperplasia (CAH) is rare worldwide. Incidence of CAH - autosomal recessive disorders characterized by enzyme defect of steroidogenic pathway, of which 90% ocuurs in the CYP21A2 gene coding 21-hydroxylase is 1:10000-16000. Incidencie of Turner syndrome is 1:2500 worldwide. Phenotypically, females with TS may present with a wide spectrum of clinical features. They may exhibit short stature, virilization, prema...

Background: As diagnostic workup and management of patients with Disorders of Sex Development (DSD) evolves, access to the latest advances should continue.Aims: To explore whether DSD patients in the West Midlands Region (WMR) remain under follow up, having optimal diagnostic workup and management.Method: An unselected cohort of 48 patients with discrepant phenotypic gender and sex chromosomes in the WMR were identified from the re...

Turner Syndrome (TS) affects 1:2500 females and is caused by the partial or complete loss of one X chromosome. About 80% of women with TS experience primary amenorrhea and therefore the only option for fertility treatment is ovum donation (OD). The remaining 20% may have the opportunity for a spontaneous pregnancy. Pregnancy in women with TS has been associated with excess obstetric risk such as miscarriage and hypertension. Maternal mortality has been estimated to be 2% risk ...

Background: Lifestyle modification is fundamental to obesity treatment, but few studies have described the effects of structured lifestyle programmes specifically in bariatric patients. We sought to describe changes in anthropometric and metabolic characteristics in a cohort of bariatric patients after participation in a nurse-led, structured lifestyle programme.Methods: We conducted a retrospective, observational cohort study of adults with a BMI ≧40...

Introduction: Most obese subjects have a normal thyroid function. Despite that, serum TSH seems to be slightly higher in this population, with a positive correlation with the degree of obesity.Objective: Evaluation of the relationship of serum TSH with BMI, weight, and HOMA-IR in euthyroid obese subjectsMethods: Three hundred obese subjects attending an Obesity Outpatient Clinic and submitted to bariatric surgery between January 20...

Introduction: Acromegaly is a rare condition associated with metabolic abnormalities, risk of cardiovascular complications and increased mortality. Even when biochemical control is achieved, following surgery or medical treatment, patients still complain about disease-related symptoms.Material and Methods: Retrospective study of acromegaly patients, followed in an Endocrine outpatient clinic. Clinical and biochemical data was recorded. ACRODAT was used t...

Introduction: GH deficiency (GHD) in adults is associated with low serum levels of insulin-like growth factor 1 (IGF1) and a deteriorated cardio-metabolic profile. GH replacement therapy (GHRT) increases serum IGF1, an important mediator of the treatment response and safety marker of dose titration. The interindividual variation in treatment response is large and most likely influenced by genetic factors.Aim: The aim of this study was to test the hypothe...

Introduction: Bariatric surgery has proved to be effective in the management of morbid obesity. Our purpose was to compare the results obtained with adjustable gastric banding (GB) and Roux-en-Y Gastric Bypass (RYGB) during 2 years of follow-up after surgery, with regard to anthropometric parameters and related comorbidities.Methods: We evaluated prospectively patients who underwent GB and RYGB between 2004 and 2010 and compared the evolution of anthropo...